SC13 Home > SC13 Schedule > SC13 Presentation - Multiscale Modeling of Fine-Grained Platelet Suspension in Coarse-Grained Blood Flow Using Molecular Dynamics and Dissipative Particle Dynamics

SCHEDULE: NOV 16-22, 2013

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Multiscale Modeling of Fine-Grained Platelet Suspension in Coarse-Grained Blood Flow Using Molecular Dynamics and Dissipative Particle Dynamics

SESSION: Doctoral Showcase - Early Research Showcase

EVENT TYPE: Doctoral Showcase - Early Research Showcases

TIME: 3:30PM - 5:00PM

SESSION CHAIR: Wojtek James Goscinski

Presenter(s):Chao Gao

ROOM:601/603

ABSTRACT:
The blood coagulation cascade may be initiated in prosthetic cardiovascular devices and cardiovascular pathologies by flow-induced platelet activation, leading to thrombus formation. Platelets undergo complex biochemical and morphological changes upon activation, aggregate, and adhere to blood vessels or device surfaces to form thrombi. Blood coagulation is inherently a multiscale problem: numerical simulations of this complex process traditionally treat blood as a continuum, typically by solving the Navier-Stokes equations to resolve the process to μm scales at the most. However, molecular mechanisms governing blood coagulation are on the nm scales. To address this challenge, we developed a multiscale approach based on Dissipative Particle Dynamics (DPD) and Coarse Grained Molecular Dynamics (CGMD) methods to bridge the gap between macroscopic flow and cellular scales. This model provides greater resolution for simulating platelets dynamics and kinematics and will be employed to simulate flow induced platelet shape change upon activation.

Chair/Presenter Details:

Wojtek James Goscinski (Chair) - Monash University

Chao Gao - Stony Brook University

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